Debilitating syndrome is a kind of non-healthy and non-disabled state caused by the decline of the elderly's physiological reserves and the decline of anti-stress capacity, or the continuous accumulation of health defects, which reduces its ability to resist stress and significantly increases the risk of adverse events.

Ni Jindong's research group explored the classification method of debilitating subtypes. On the basis of traditional debilitating assessment, statistical techniques were used to reveal the potential aggregation patterns of the elderly's multidimensional health problems. Four types of debilitating subtypes of old age were preliminarily distinguished. Physiological weakness, cognitive and functional weakness, and psychological weakness; at the same time, research on the immunological signs of degeneration and the possible mechanism of occurrence, and found the association of Tfh cell subsets with the three weak subtypes, related research results were continuously published in Aging (Albany NY ) The second and third phases of this year provide a theoretical basis for the research on the mechanism of proven weakness and precise prevention. (Test article)